Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice1

Postnatal Growth Responses to Insulin-Like Growth

Organ weight was compared in adult mice with deletion of one (IRS-1) or both (IRS-1) copies of the insulin receptor substrate-1 (IRS-1) gene and IRS-1 littermates. IRS-1 mice showed modest reductions in weight of most organs in proportion to a decrease in body weight. IRS-1 mice showed major reductions in weight of heart, liver, and spleen that were directly proportional to a decrease in body w...

Consequences of postnatal insulin-like growth factor II overexpression in insulin-like growth factor I deficient mice

Insulin-like growth factor I gene polymorphism associated with growth traits in beluga (Huso huso) fish

The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...

Insulin-like growth factor I gene polymorphism associated with growth traits in beluga (Huso huso) fish

The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...

Insulin-like growth factor I is essential for postnatal growth in response to growth hormone.

Insulin-like growth factor I (IGF-I) is essential for cell growth and intrauterine development while both IGF-I and GH are required for postnatal growth. To explore the possibility of direct GH action on body growth, independent of IGF-I production, we have studied the effects of GH in an IGF-I-deficient mouse line created by the Cre/loxP system. The IGF-I null mice are born with 35% growth ret...